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TB-500 is a synthetic peptide corresponding to the active region of thymosin beta-4 (Tβ4), a naturally occurring 43-amino acid peptide originally isolated from the thymus gland. As one of the most abundant intracellular proteins, thymosin beta-4 plays a central role in actin cytoskeletal dynamics through its high-affinity binding to G-actin (globular actin) monomers.
The compound's primary mechanism of interest in research settings centers on its actin-sequestering properties. TB-500 binds to the actin monomer pool, modulating the polymerization-depolymerization equilibrium that governs cytoskeletal organization. This interaction has been extensively characterized through in-vitro binding assays, crystallography studies, and cell-based models. Published research has also explored TB-500's interactions with signaling pathways involving Akt/mTOR, VEGF, and various interleukin cascades in laboratory models.
AXOM TB-500 is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 5mg lyophilized format. For research and laboratory use only.
High-affinity G-actin sequestering peptide that modulates cytoskeletal dynamics, enabling detailed research into actin polymerization and cellular organization.
Synthetic active region of thymosin beta-4, one of the most abundant intracellular proteins, providing a well-characterized tool for in-vitro pathway analysis.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Comprehensive review of thymosin beta-4 biology spanning decades of research. Examines the peptide's role in actin cytoskeletal regulation, its interactions with G-actin monomers, and the downstream signaling pathways characterized through in-vitro and preclinical models.
Examines the molecular properties of thymosin beta-4 in cell-based assay systems. Characterizes the peptide's signaling pathway interactions and its effects on cell migration and proliferation markers in controlled laboratory conditions.
Explores the role of thymosin beta-4 in cardiovascular research models. Detailed analysis of the actin-binding peptide's interactions with Akt/mTOR and VEGF signaling pathways as characterized through standardized in-vitro assay protocols.
| Product Name | TB-500 (Thymosin Beta-4 Fragment) |
| Synonyms | TB-500, TB500, Thymosin Beta 4, Tβ4 |
| CAS Number | 77591-33-4 |
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | ~4,963.44 Da |
| Sequence Length | 43 amino acids (active region of Thymosin Beta-4) |
| Mechanism | Actin-sequestering peptide (G-actin binding) |
| Parent Protein | Thymosin Beta-4 (Tβ4) |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 5mg |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
TB-500 is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
