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Human Chorionic Gonadotropin (HCG) is a naturally occurring dimeric glycoprotein composed of two non-covalently linked subunits: an alpha (α) subunit shared with other glycoprotein hormones (LH, FSH, TSH), and a unique beta (β) subunit that confers biological specificity. With a molecular weight of approximately 36,700 Da, HCG is among the larger peptide-class research reagents and has been the subject of extensive published literature spanning reproductive biology, endocrinology, and molecular signaling research.
In preclinical and in-vitro research settings, HCG has been studied for its interactions with the luteinizing hormone/choriogonadotropin receptor (LHCGR), a G protein-coupled receptor. Published studies have characterized HCG's role in cAMP signaling cascades, steroidogenesis pathway modulation, and glycoprotein receptor binding kinetics. The molecule's complex glycosylation patterns have also made it a valuable model compound for glycobiology and post-translational modification research.
AXOM HCG is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC and bioactivity assay. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, bioactivity, and endotoxin levels. Available in 5000IU lyophilized format. For research and laboratory use only.
Two-subunit glycoprotein with unique beta chain conferring biological specificity — a well-characterized model for glycoprotein receptor interaction studies.
High-affinity ligand for the luteinizing hormone/choriogonadotropin receptor, enabling targeted investigation of G protein-coupled receptor signaling cascades.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Foundational review characterizing the molecular structure of HCG, including its dimeric glycoprotein architecture, alpha and beta subunit composition, and carbohydrate moieties. Details the biosynthetic pathways and regulatory mechanisms governing HCG expression in trophoblastic cell models.
X-ray crystallographic determination of the three-dimensional structure of HCG at 2.6 Å resolution. Revealed the cystine-knot motif shared among glycoprotein hormones and characterized the molecular basis for receptor binding specificity conferred by the beta subunit.
Comprehensive review of the LHCGR receptor structure, ligand binding domains, and downstream signaling pathways. Discusses in-vitro binding assay data characterizing HCG-receptor interaction kinetics, cAMP signal transduction, and receptor desensitization mechanisms.
| Product Name | HCG (Human Chorionic Gonadotropin) |
| Synonyms | hCG, Choriogonadotropin, Chorionic Gonadotrophin |
| CAS Number | 9002-61-3 |
| Molecular Weight | ~36,700 Da (glycoprotein) |
| Structure | Heterodimeric glycoprotein (α + β subunits) |
| Alpha Subunit | 92 amino acids (shared with LH, FSH, TSH) |
| Beta Subunit | 145 amino acids (unique, confers specificity) |
| Glycosylation | N-linked and O-linked carbohydrate moieties |
| Target Receptor | LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor) |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 5000IU |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
HCG is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
