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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a cell-permeable small molecule that functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is an enzyme involved in the methylation of nicotinamide, utilizing S-adenosyl-L-methionine (SAM) as a methyl donor. This compound has garnered significant attention in preclinical metabolic research for its ability to modulate cellular NAD+ metabolism and energy expenditure pathways in in-vitro and in-vivo models.
As a quinolinium derivative with a molecular weight of just 173.21 Da, 5-Amino-1MQ is notably smaller than traditional peptide research compounds. Its small molecular size contributes to favorable cell membrane permeability characteristics observed in laboratory assays. Published preclinical studies have investigated its interactions with adipocyte differentiation pathways, SAM-dependent methylation cascades, and intracellular NAD+ salvage mechanisms.
AXOM 5-Amino-1MQ is manufactured under strict quality control protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, and residual solvent levels. Available in 5mg lyophilized format. For research and laboratory use only.
Selective small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), enabling targeted research into methylation-dependent metabolic pathways and NAD+ homeostasis.
Low molecular weight (173.21 Da) quinolinium compound with favorable membrane permeability characteristics, facilitating efficient cellular uptake in in-vitro assay systems.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Investigated the effects of 5-Amino-1MQ on NNMT activity and BMP signaling in adipocyte cell cultures and preclinical animal models. Demonstrated that selective NNMT inhibition modulated SAM-dependent methylation pathways and BMP7 expression in adipose tissue explants under controlled laboratory conditions.
Examined the role of NNMT inhibition via 5-Amino-1MQ in aged muscle stem cell populations using in-vitro culture systems and preclinical animal models. Characterized the compound's effects on satellite cell activation markers, NAD+ metabolite levels, and myogenic differentiation pathway signaling.
Landmark study establishing NNMT as a key regulator of cellular energy metabolism. Demonstrated through in-vitro knockdown experiments and preclinical models that NNMT modulation affected SAM and NAD+ metabolite flux, polyamine synthesis, and energy expenditure parameters in adipose and hepatic tissue cultures.
| Product Name | 5-Amino-1MQ (5-Amino-1-methylquinolinium) |
| Synonyms | 5-Amino-1-methylquinolinium, 5-Amino-1MQ |
| CAS Number | 42899-83-8 |
| Molecular Formula | C10H11NO2 |
| Molecular Weight | 173.21 Da |
| Compound Type | Small molecule — quinolinium derivative |
| Target | Nicotinamide N-methyltransferase (NNMT) |
| Mechanism | Selective NNMT inhibitor |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 5mg |
| Solubility | Soluble in DMSO, water |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
5-Amino-1MQ is supplied as a lyophilized powder and should be reconstituted with an appropriate solvent for research applications.
All orders ship within the continental United States via USPS or UPS. Products are shipped at ambient temperature — lyophilized compounds are stable during transit. Free shipping on orders over $250.
