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Melanotan-1 (also known as Afamelanotide) is a synthetic linear tridecapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). With the sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 and a molecular weight of 1,646.85 Da, Melanotan-1 incorporates key structural modifications — including norleucine (Nle) at position 4 and D-phenylalanine (D-Phe) at position 7 — that confer enhanced receptor binding affinity and enzymatic stability compared to the native α-MSH peptide.
In preclinical and in-vitro research settings, Melanotan-1 has been extensively studied for its interactions with the melanocortin receptor family, particularly the MC1R (melanocortin-1 receptor). Published studies have characterized its selective agonist activity at MC1R, its role in melanogenesis pathway signaling via cAMP/PKA cascades, and its structure-activity relationships within the melanocortin peptide class. The D-Phe substitution at position 7 has been of particular interest in peptide engineering research for its contribution to protease resistance.
AXOM Melanotan-1 is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC and mass spectrometry. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 10mg lyophilized format. For research and laboratory use only.
Structurally modified 13-amino-acid analog of alpha-melanocyte-stimulating hormone with enhanced receptor affinity and enzymatic stability for melanocortin receptor research.
Selective agonist at the melanocortin-1 receptor, enabling targeted investigation of MC1R-mediated cAMP/PKA signaling cascades and melanogenesis pathways.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Foundational structure-activity relationship study characterizing the design principles of superpotent α-MSH analogs. Demonstrates the critical role of Nle4 and D-Phe7 substitutions in enhancing melanocortin receptor binding affinity and proteolytic stability in cell-based assays.
Comprehensive review of melanocortin receptor pharmacology with detailed characterization of Melanotan-1 binding profiles across MC1R through MC5R receptor subtypes. Discusses in-vitro binding assay data, cAMP accumulation studies, and structure-function analysis of linear vs. cyclic melanocortin analogs.
In-vitro investigation characterizing afamelanotide-mediated activation of the melanocortin signaling pathway in human melanocyte cell cultures. Examines MC1R-dependent cAMP generation, eumelanin synthesis markers, and downstream gene expression profiles using qPCR and ELISA-based assay platforms.
| Product Name | Melanotan-1 (Afamelanotide) |
| Synonyms | MT-1, MT-I, Afamelanotide, [Nle4, D-Phe7]-α-MSH, NDP-MSH, CUV1647 |
| CAS Number | 75921-69-6 |
| Molecular Formula | C78H111N21O19 |
| Molecular Weight | 1,646.85 Da |
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Sequence Length | 13 amino acids (linear tridecapeptide) |
| Key Modifications | Nle4 (norleucine), D-Phe7 (D-phenylalanine), N-terminal acetylation, C-terminal amidation |
| Target Receptor | MC1R (Melanocortin-1 Receptor, selective agonist) |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 10mg |
| Solubility | Soluble in sterile water, bacteriostatic water, DMSO |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
Melanotan-1 is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
