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Peptides

Melanotan-1

Afamelanotide — Melanocortin Receptor Agonist Research Compound
In Stock

Melanotan-1 (Afamelanotide) is a 13-amino acid synthetic melanocortin receptor agonist (CAS: 75921-69-6, MW: 1646.85 Da) studied in dermatological and photoprotection research. Supplied as ≥99% HPLC-verified lyophilized powder. For research use only.

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≥99% Purity
cGMP Certified
3-Day Delivery
Melanotan-1
Melanotan-1
10mg • 1 Vial
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α-MSH Analog

Synthetic tridecapeptide analog of alpha-melanocyte stimulating hormone

≥99% HPLC Purity

Every lot independently verified by third-party laboratories

COA Included

Full Certificate of Analysis with HPLC, mass spec, and endotoxin data

What is Melanotan-1?

Melanotan-1 (also known as Afamelanotide) is a synthetic tridecapeptide (13-amino acid) analog of alpha-melanocyte-stimulating hormone (α-MSH), developed at the University of Arizona. It features a Nle⁴-D-Phe⁷ substitution that enhances receptor binding and metabolic stability.

Published research has examined Melanotan-1's selective binding to the melanocortin 1 receptor (MC1R) and its downstream effects on melanogenesis signaling pathways in cell culture and animal models.

Manufactured under cGMP-equivalent protocols and verified to ≥99% purity via HPLC. Full COA included with every order.

Supplied as a lyophilized white powder. Soluble in sterile water. For research and laboratory use only.

Specifications

CAS Number 75921-69-6
Molecular Formula C₇₈H₁₁₁N₂₁O₁₉
Molecular Weight ~1,646.85 Da
Sequence 13 amino acids (α-MSH analog)
Targets MC1R (Melanocortin 1 Receptor)
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage -20°C (lyophilized)
Published Research

Peer-Reviewed Studies

Afamelanotide and narrowband UV-B phototherapy for the treatment of vitiligo Lim HW, et al. • JAMA Dermatol, 2015
[Nle4, D-Phe7]-alpha-melanocyte-stimulating hormone: a superpotent melanotropin Sawyer TK, et al. • PNAS, 1980
Melanocortin 1 receptor signaling and photoprotection Wolf Horrell EM, et al. • Peptides, 2016
Common Questions

Melanotan-1 FAQ

Melanotan-1 is a synthetic tridecapeptide analog of α-MSH that selectively targets the MC1R receptor. It is intended exclusively for in-vitro and laboratory research.

Verified at ≥99% purity via reverse-phase HPLC. Each lot includes mass spectrometry confirmation. Full COA included.

Lyophilized: -20°C long-term, stable at 2–8°C for 90 days. Reconstituted: 2–8°C, use within 28 days. Protect from light.

Yes. Every order includes a lot-specific COA with HPLC chromatography, mass spec data, and peptide content.

Orders before 2PM EST ship same day. Standard delivery is 2–4 business days within the continental US. All orders include tracking.

Still have questions about Melanotan-1 or any of our research compounds?

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