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Epithalon (also known as Epitalon or Epithalone) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly. Originally characterized in research conducted at the Saint Petersburg Institute of Bioregulation and Gerontology, Epithalon is a synthetic analog of the naturally occurring polypeptide Epithalamin, which was isolated from the pineal gland. This four-amino-acid peptide has been the subject of published research investigating its interactions with telomerase activity and pineal gland function in in-vitro and preclinical settings.
Published studies have examined Epithalon's influence on telomerase reverse transcriptase (TERT) gene expression in cultured cell lines, as well as its interactions with melatonin synthesis pathways in pineal gland tissue models. The peptide's relatively small size (390.35 Da) and defined sequence make it a well-characterized tool for laboratory investigations into telomere biology and neuroendocrine signaling cascades.
AXOM Epithalon is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 40mg lyophilized format. For research and laboratory use only.
Defined 4-amino acid synthetic peptide (Ala-Glu-Asp-Gly) — a characterized analog of the pineal-derived polypeptide Epithalamin, enabling targeted molecular pathway research.
Published in-vitro studies have examined this peptide's interactions with telomerase reverse transcriptase (TERT) gene expression in cultured human somatic cell lines.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
In-vitro investigation examining the effects of Epithalon on telomerase catalytic subunit (hTERT) expression and telomere length in cultured human fetal fibroblasts and adult pulmonary fibroblast cell lines. Characterized peptide-mediated changes in telomerase activity using TRAP assay methodology under controlled laboratory conditions.
Extended cell culture study examining Epithalon's effects on telomerase activation and replicative lifespan parameters in human somatic cell lines. Demonstrated measurable changes in hTERT mRNA expression levels via RT-PCR analysis in peptide-treated versus control cell populations across multiple passages.
Preclinical study examining long-term administration of Epithalon in female SHR mouse models. Characterized the peptide's effects on melatonin production patterns, reproductive function markers, and spontaneous tumor incidence rates in an age-matched controlled cohort study design.
| Product Name | Epithalon (Epitalon / Epithalone) |
| Synonyms | Epitalon, Epithalone, Epithalon tetrapeptide |
| CAS Number | 307297-39-8 |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 Da |
| Sequence | Ala-Glu-Asp-Gly |
| Sequence Length | 4 amino acids (tetrapeptide) |
| Origin | Synthetic analog of pineal gland-derived Epithalamin |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 40mg |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
Epithalon is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
