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GHK-Cu is a naturally occurring copper-binding tripeptide first identified in human plasma by Dr. Loren Pickart in 1973. Comprising the amino acid sequence glycine-histidine-lysine with a bound copper(II) ion, this compact tripeptide-metal complex has been the subject of extensive published research spanning over four decades of in-vitro and preclinical investigation.
The GHK tripeptide binds copper with high affinity, forming a 1:1 complex at physiological pH. Structurally, the copper ion coordinates through the nitrogen atoms of the peptide backbone and the imidazole side chain of histidine, creating a stable chelate that has been characterized by X-ray crystallography and spectroscopic methods. This copper-peptide interaction is central to the compound's observed biological activity in laboratory models.
AXOM GHK-Cu is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, copper content, and endotoxin levels. Available in 50mg and 100mg lyophilized formats. For research and laboratory use only.
Stable 1:1 copper(II)-peptide chelate with high binding affinity at physiological pH, enabling copper-dependent research applications in controlled laboratory settings.
Minimal three-amino-acid sequence (Gly-His-Lys) with well-characterized molecular structure confirmed by crystallography and spectroscopic analysis.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Comprehensive review of GHK-Cu research spanning multiple decades. Examines the tripeptide-copper complex's role in gene expression modulation, documenting its effects on over 4,000 human genes in microarray studies. The review consolidates in-vitro data on the compound's interaction with antioxidant and protective gene pathways.
Detailed analysis of GHK-copper complex signaling mechanisms in cell culture models. The study maps peptide-mediated copper delivery pathways and their downstream effects on extracellular matrix protein expression, providing foundational data for understanding tripeptide-metal complex interactions in biological systems.
In-vitro investigation of GHK-Cu effects on dermal fibroblast cultures examining collagen synthesis, glycosaminoglycan production, and cellular proliferation markers. Provides quantitative data on the copper tripeptide complex's activity in standardized cell culture assay systems.
| Product Name | GHK-Cu (Copper Tripeptide Complex) |
| Synonyms | Copper Peptide GHK-Cu, Glycyl-L-Histidyl-L-Lysine:Copper(II) |
| CAS Number | 49557-75-7 |
| Molecular Formula | C14H24N6O4Cu |
| Molecular Weight | ~403.93 Da |
| Sequence | Gly-His-Lys (3 amino acids, tripeptide) |
| Metal Ion | Copper(II), 1:1 stoichiometry |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized blue powder |
| Available Sizes | 50mg, 100mg |
| Solubility | Freely soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
GHK-Cu is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
