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AOD-9604 (Advanced Obesity Drug-9604) is a synthetic 16-amino acid peptide corresponding to a modified fragment (residues 177-191) of human growth hormone (hGH). With a molecular weight of 1,815.08 Da (CAS: 221231-10-3) and the molecular formula C₇₈H₁₂₃N₂₃O₂₃S₂, this peptide contains a disulfide bond that stabilizes its tertiary structure and is critical to its characterized biological activity in research models.
Published research has demonstrated that AOD-9604 retains the lipolytic activity associated with the C-terminal fragment of hGH while lacking somatogenic (growth-promoting) properties. In-vitro studies have characterized its interactions with the beta-3 adrenergic receptor pathway and its effects on lipid metabolism in adipocyte cell culture systems. This dissociation of lipolytic and somatogenic activities has made AOD-9604 a compound of significant interest in metabolic research.
AXOM AOD-9604 is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 5mg lyophilized format. For research and laboratory use only.
16-amino acid peptide derived from the C-terminal region (177-191) of human growth hormone with a stabilizing disulfide bond, enabling targeted metabolic pathway research.
Retains characterized lipolytic properties of the hGH C-terminal domain without somatogenic activity, enabling isolated metabolic signaling studies in adipocyte models.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Foundational characterization of AOD-9604 as a modified hGH fragment. Demonstrates through in-vitro lipolysis assays and adipocyte cell culture models that the peptide retains lipolytic activity without stimulating IGF-1 production or exhibiting growth-promoting properties.
Mechanistic study examining the interaction between hGH C-terminal fragments (including AOD-9604) and the beta-3 adrenergic receptor signaling pathway. Characterizes lipid mobilization kinetics in differentiated adipocyte cell lines under controlled laboratory conditions.
In-vitro study using 3T3-L1 adipocyte cell culture to characterize the lipolytic activity of hGH C-terminal fragments. Demonstrates fragment-specific stimulation of glycerol release and free fatty acid mobilization using standardized lipolysis assay protocols.
| Product Name | AOD-9604 (Advanced Obesity Drug-9604) |
| Synonyms | AOD-9604, AOD9604, hGH Fragment 177-191 (modified) |
| CAS Number | 221231-10-3 |
| Molecular Formula | C78H123N23O23S2 |
| Molecular Weight | 1,815.08 Da |
| Sequence | Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe (Cys disulfide bond) |
| Sequence Length | 16 amino acids |
| Origin | Modified C-terminal fragment (177-191) of human growth hormone |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 5mg |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
AOD-9604 is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
