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SLU-PP-332 is a small molecule agonist of the estrogen-related receptors alpha and gamma (ERRα and ERRγ). These orphan nuclear receptors are key transcriptional regulators of oxidative metabolism, mitochondrial biogenesis, and fatty acid oxidation gene programs. Developed at Saint Louis University, SLU-PP-332 was identified through structure-activity relationship studies as a potent and selective ERR agonist suitable for preclinical research applications.
Published preclinical studies have characterized SLU-PP-332 as an "exercise mimetic" compound — a research tool that activates transcriptional programs associated with endurance exercise adaptations in skeletal muscle tissue models. In-vitro and in-vivo studies have demonstrated that ERR activation by SLU-PP-332 upregulates genes involved in mitochondrial electron transport chain assembly, fatty acid β-oxidation, and oxidative phosphorylation pathways in cultured myocyte cell lines and preclinical animal models.
AXOM SLU-PP-332 is manufactured under strict quality control protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, and analytical characterization data. Available in 10mg lyophilized format. For research and laboratory use only.
Selective agonist of estrogen-related receptors α and γ (ERRα/γ), enabling targeted research into orphan nuclear receptor-mediated transcriptional programs and metabolic gene regulation.
Characterized in published preclinical studies as an exercise mimetic compound that activates transcriptional programs associated with endurance exercise adaptations in skeletal muscle models.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Landmark study characterizing SLU-PP-332 as an ERRα/γ agonist that activates exercise-associated transcriptional programs in preclinical models. Demonstrated that compound administration enhanced oxidative muscle fiber gene expression, mitochondrial respiration parameters, and fatty acid oxidation markers in skeletal muscle tissue of murine models under controlled experimental conditions.
Structure-activity relationship study detailing the development and optimization of SLU-PP-332 as a selective ERR agonist. Characterized binding affinity, receptor selectivity profiles, and transcriptional activation potency using luciferase reporter assays and in-vitro binding displacement experiments across the ERR receptor family.
Comprehensive review of the ERR family of orphan nuclear receptors and their roles in cellular metabolism. Examines the transcriptional networks controlled by ERRα, ERRβ, and ERRγ in mitochondrial biogenesis, oxidative phosphorylation, and lipid metabolism, providing context for the development of selective ERR modulators as research tools.
| Product Name | SLU-PP-332 |
| Synonyms | SLU-PP-332, SLUPP332 |
| CAS Number | 1628607-64-0 |
| Molecular Formula | C24H22N2O4S |
| Molecular Weight | 434.49 Da |
| Compound Type | Small molecule — ERRα/γ agonist |
| Target | Estrogen-related receptors alpha and gamma (ERRα/ERRγ) |
| Mechanism | Selective ERR agonist (exercise mimetic) |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized powder |
| Available Sizes | 10mg |
| Solubility | Soluble in DMSO |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
SLU-PP-332 is supplied as a lyophilized powder and should be reconstituted with an appropriate solvent for research applications.
All orders ship within the continental United States via USPS or UPS. Products are shipped at ambient temperature — lyophilized compounds are stable during transit. Free shipping on orders over $250.
