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Peptides

MOTS-C

Mitochondrial-Derived Peptide — Metabolic Research Compound
Concentration
In Stock

MOTS-C is a mitochondrial-derived 16-amino acid peptide studied for metabolic regulation, insulin sensitivity, and exercise mimetic activity in research models. ≥99% HPLC-verified. For research use only.

Quantity
1
Vial
$59.99
$59.99 / vial
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2
Vials
$99.99
$50.00 / vial
You save $19.99
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3
Vials
$139.99
$46.66 / vial
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≥99% Purity
cGMP Certified
3-Day Delivery
MOTS-C
MOTS-C
10mg • 1 Vial
Save 17%
Save 22%
Mitochondrial Peptide

16-amino acid peptide encoded within the mitochondrial genome

≥99% HPLC Purity

Every lot independently verified by third-party laboratories

COA Included

Full Certificate of Analysis with HPLC, mass spec, and endotoxin data

What is MOTS-C?

MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene, discovered by Dr. Changhan David Lee's laboratory at USC in 2015.

Published research has examined MOTS-C's role in AMPK pathway activation, folate-methionine cycle regulation, and cellular metabolic homeostasis in preclinical models. It represents a novel class of mitochondria-derived peptides (MDPs).

Manufactured under cGMP-equivalent protocols and verified to ≥99% purity via HPLC. Full COA included with every order.

Supplied as a lyophilized white powder. Soluble in sterile water. For research and laboratory use only.

Specifications

CAS Number 1627580-64-6
Molecular Formula C₁₀₁H₁₅₂N₂₈O₂₅S₂
Molecular Weight ~2,174.64 Da
Sequence 16 amino acids
Targets AMPK Pathway
Purity ≥99% (HPLC)
Form Lyophilized powder
Storage -20°C (lyophilized)
Published Research

Peer-Reviewed Studies

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity Lee C, et al. • Cell Metabolism, 2015
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline Reynolds JC, et al. • Nat Commun, 2021
MOTS-c activates AMPK and the folate cycle to promote cellular metabolic homeostasis Kim KH, et al. • Cell Rep, 2018
Common Questions

MOTS-C FAQ

MOTS-C is a 16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA gene. It is intended exclusively for in-vitro and laboratory research applications.

Verified at ≥99% purity via reverse-phase HPLC. Each lot includes mass spectrometry confirmation. Full COA included with every order.

Lyophilized: -20°C long-term, stable at 2–8°C for 90 days. Reconstituted: 2–8°C, use within 28 days. Protect from light.

Yes. Every order includes a lot-specific COA with HPLC chromatography, mass spec data, peptide content, and endotoxin levels.

Orders before 2PM EST ship same day. Standard delivery is 2–4 business days within the continental US. All orders include tracking.

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