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MOTS-c is a 16-amino acid peptide encoded by the mitochondrial genome within the 12S ribosomal RNA (rRNA) gene. First identified and characterized by Lee et al. in 2015, MOTS-c represents the first mitochondrial-derived peptide (MDP) demonstrated to regulate metabolic homeostasis in published research models, establishing a novel class of signaling molecules encoded by mitochondrial DNA (mtDNA).
Published research has characterized MOTS-c as a retrograde signaling peptide that translocates to the nucleus and regulates gene expression through interaction with antioxidant response elements (ARE). Studies have demonstrated its involvement in the AMPK signaling pathway and the folate-methionine cycle, modulating cellular metabolism at the transcriptional level. The mitochondrial origin of MOTS-c has made it a subject of significant research interest in the field of mitochondrial biology and inter-organelle communication.
AXOM MOTS-C is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 20mg lyophilized format for research use only.
First identified mitochondrial-derived peptide (MDP) encoded by the 12S rRNA gene of mtDNA — a novel class of retrograde signaling molecules studied in mitochondrial biology research.
Characterized in published literature for AMPK pathway engagement and involvement in the folate-methionine cycle, regulating cellular metabolic homeostasis in laboratory models.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Discovery paper identifying MOTS-c as the first mitochondrial-derived peptide with demonstrated metabolic regulatory activity. Characterized the peptide's encoding within the mitochondrial 12S rRNA gene, its AMPK-dependent signaling mechanism, and its role in modulating the folate cycle and de novo purine biosynthesis in cellular assays.
Study characterizing MOTS-c as an exercise-responsive mitochondrial signal in preclinical models. Demonstrated that endogenous MOTS-c levels are modulated by physical activity and characterized its nuclear translocation and interaction with antioxidant response element (ARE) motifs to regulate stress-adaptive gene expression programs.
Comprehensive review of the emerging class of mitochondrial-derived peptides including MOTS-c and humanin. Details the retrograde signaling paradigm whereby mtDNA-encoded peptides regulate nuclear gene expression and cellular metabolism, with MOTS-c highlighted as a key regulator of the AMPK-AICAR axis in published research.
| Product Name | MOTS-c (Mitochondrial ORF of the 12S rRNA Type-c) |
| Synonyms | MOTS-c, Mitochondrial-Derived Peptide |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C101H152N28O22S2 |
| Molecular Weight | ~2,174.45 Da |
| Sequence Length | 16 amino acids (encoded by mitochondrial 12S rRNA gene) |
| Origin | Mitochondrial DNA-encoded (12S rRNA ORF) |
| Signaling Pathway | AMPK, folate-methionine cycle, ARE-mediated transcription |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Size | 20mg |
| SKU | LTF-MC-20 |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
MOTS-C is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
