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Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide first isolated from cerebral venous blood of rabbits in 1977 by Schoenenberger and Monnier. Composed of nine amino acids (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu), DSIP has a molecular weight of 848.81 Da and has been the subject of extensive published research across neuroendocrinology, chronobiology, and molecular neuroscience.
In preclinical and in-vitro research settings, DSIP has been investigated for its interactions with multiple neuroendocrine pathways. Published studies have characterized its effects on delta-wave electroencephalographic patterns, its modulation of corticotropin and somatotropin release in hypothalamic-pituitary axis models, and its interactions with opioid receptor systems. The peptide's amphiphilic structure and ability to cross model membrane barriers have made it a valuable research tool in blood-brain barrier permeability studies.
AXOM DSIP is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC and mass spectrometry. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 10mg lyophilized format. For research and laboratory use only.
Nine-amino-acid neuropeptide first characterized in 1977, enabling targeted investigation of neuroendocrine signaling pathways and delta-wave electrophysiology research.
Unique amphiphilic molecular properties allow membrane permeability studies — a valuable model compound for blood-brain barrier transport research.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Foundational review synthesizing early research on DSIP's characterization, including its isolation from rabbit cerebral venous blood, peptide sequencing, and initial electrophysiological observations in preclinical models. Examines structure-activity relationships and analytical methodology.
Comprehensive examination of DSIP as a signal molecule in neuroendocrine models. Reviews in-vitro data on DSIP interactions with hypothalamic-pituitary signaling cascades, including modulation of corticotropin and somatotropin release in cell culture and tissue slice preparations.
In-vitro and preclinical investigation of DSIP's effects on markers of oxidative stress. Characterized the peptide's interactions with lipid peroxidation pathways and antioxidant enzyme systems using standardized biochemical assays in controlled laboratory conditions.
| Product Name | DSIP (Delta Sleep-Inducing Peptide) |
| Synonyms | DSIP, Delta Sleep Peptide, Emideltide |
| CAS Number | 62568-57-4 |
| Molecular Formula | C35H48N10O15 |
| Molecular Weight | 848.81 Da |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Sequence Length | 9 amino acids (nonapeptide) |
| Origin | First isolated from rabbit cerebral venous blood (1977) |
| Structure | Linear amphiphilic nonapeptide |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 10mg |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
DSIP is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
