21+
Age Verification
You must be 21 years of age or older to enter this site.
By entering, you confirm you are 21 years of age or older.
You must be 21 years of age or older to enter this site.
By entering, you confirm you are 21 years of age or older.
Semax is a synthetic heptapeptide analogue of the adrenocorticotropic hormone (ACTH) fragment spanning positions 4 through 10. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, Semax extends the native ACTH(4-7) sequence (Met-Glu-His-Phe) with a C-terminal Pro-Gly-Pro tripeptide, yielding the full sequence Met-Glu-His-Phe-Pro-Gly-Pro. This structural modification provides enhanced enzymatic stability compared to the parent ACTH fragment.
The compound retains the core melanocortin pharmacophore of ACTH while the Pro-Gly-Pro C-terminal extension confers resistance to degradation by serum peptidases. Published preclinical research has characterized Semax's interaction with melanocortin receptor subtypes and documented its effects on neurotrophic factor expression in various in-vitro model systems. The heptapeptide has been extensively studied in peer-reviewed literature spanning multiple decades.
AXOM Semax is manufactured under strict cGMP-equivalent protocols and verified to ≥99% purity via reverse-phase HPLC. Each lot is accompanied by a Certificate of Analysis documenting identity, purity, peptide content, and endotoxin levels. Available in 5mg and 10mg lyophilized formats. For research and laboratory use only.
Synthetic analogue of the ACTH(4-10) fragment retaining the core melanocortin pharmacophore with enhanced stability for in-vitro receptor binding and signaling studies.
Seven-amino-acid neuropeptide (Met-Glu-His-Phe-Pro-Gly-Pro) with documented effects on neurotrophic factor expression in published preclinical models.
≥99% HPLC-verified purity with full COA documentation. Every lot independently tested by third-party analytical laboratories.
Comprehensive pharmacological overview of the Semax heptapeptide examining its receptor binding profile, metabolic stability, and downstream signaling pathway engagement. Reviews two decades of published research on the ACTH fragment analogue, including receptor selectivity data and structure-activity relationship characterization.
In-vivo study examining Semax's influence on BDNF, NGF, and NT-3 expression levels and their corresponding receptor systems in brain tissue. Provides quantitative mRNA and protein expression data demonstrating the heptapeptide's modulatory effects on neurotrophic signaling cascades in controlled experimental conditions.
Study characterizing Semax-mediated changes in immune response gene expression profiles using microarray and quantitative PCR methodologies. Documents the ACTH analogue's effects on cytokine, chemokine, and immunomodulatory gene networks, providing transcriptomic evidence for peptide-mediated signaling pathway regulation.
| Product Name | Semax (ACTH(4-10) Analogue) |
| Synonyms | ACTH(4-10)-Pro-Gly-Pro, Heptapeptide Semax |
| CAS Number | 80714-61-0 |
| Molecular Formula | C37H51N9O10S |
| Molecular Weight | ~813.93 Da |
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro (7 amino acids) |
| Parent Fragment | ACTH(4-7) (Met-Glu-His-Phe) + Pro-Gly-Pro extension |
| Purity | ≥99% (Reverse-Phase HPLC) |
| Form | Lyophilized white powder |
| Available Sizes | 5mg, 10mg |
| Solubility | Soluble in sterile water, bacteriostatic water |
| Endotoxin | <1 EU/μg (LAL method) |
| Certification | COA included with every order |
| Intended Use | For research and laboratory use only |
Semax is supplied as a lyophilized powder and should be reconstituted with sterile bacteriostatic water (BAC water) for research applications.
All orders ship within the continental United States via USPS or UPS. Peptides are shipped at ambient temperature — lyophilized peptides are stable during transit. Free shipping on orders over $250.
